Abstract
Abstract Thoracic duct cells and spleen cells from normal and immunized Lewis rats were injected into syngeneic recipients which had received 500 R x-irradiation 2 hr earlier. Tetanus and diphtheria toxoids were injected 24 hr after irradiation and the antibody response was measured for 2 to 3 weeks thereafter. Immunologically competent units were detected in normal spleen cells but not in normal thoracic duct cells. Immunization of the cell donors produced at least a 103- to 104-fold increase in units in the thoracic duct lymph and a much smaller increase in units in the spleen resulting in a change in the distribution (relative concentrations) of units in these lymphoid tissues.
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