Initial serum transaminase levels predict outcomes in patients with acute ST-segment elevation myocardial infarction who undergo primary percutaneous coronary intervention

Abstract

Objective To evaluate the prevalence and prognostic implications of hypoxic liver injury(HLI)in acute ST-segment elevation myocardial infarction(STEMI). Methods Patients with STEMI who had undergone primary percutaneous coronary intervention(PCI)were enrolled from January 2013 to August 2015.Patients’ medical records were reviewed and their families were interviewed via telephone to assess the outcomes. Results Of the 622 STEMI patients(aged 62(18)years, with 534 males), 37 patients(5.9%)died during the follow-up(duration: 632(495)days). These patients were older and had higher AST 625(695)U/L vs.247(236)U/L, ALT 123(133)U/L, vs.52(42)U/L, creatine kinase-myocardial band isoenzyme 248.5(407.5)ng/ml vs.184.7(197.0)ng/ml and troponin I 80.0(30.4)ng/ml vs.49.6(61.6)ng/ml from the initial tests at the hospital.Particularly, AST and ALT independently predicted all-cause mortality. Conclusions The presence of HLI is common and predicts mortality in patients with STEMI who undergo primary PCI. Key words: Transaminases; Myocardial infarction; Liver