Initial response to treatment (Rx) and need for intensified (step-up) therapy in children with newly diagnosed, inflammatory bowel disease (IBD): A preliminary investigation by the pediatric IBD collaborative research group

Abstract

respectively (p=NS). The probabdity of moderately acnve disease did not demonstrate significant dilfi:mnce with NSA1D use, though CD patients on high-dose NSA1Ds had a 1,27dbld increase likelihood of moderately active disease as compared with patients on noNSAIDs. Subgroup analysis showed die increase in disease activity among CD patients taking high-dose NSAIDs was limited to patients with colonic niw~lvement. For CD patients with limited ileal involvement the MHB scorn was 4.01 with no-NSAIDs and 3.85 on high-dose NSAIDs. CD patients with ileocolonic or isolated colonic disease had an MHB score of 4.11 with noNSAIDs but increased to 5 47 with high-dose NSAIDs (p = 0.008). Among the UC patients, there was a trend towards a higher disease activity score among patients with pancofitiS(as opposed to distal disease). The LS increa~d from 5.79 to 7.43 comparing the pancofitis no-NSAIDs vs. high-dose NSAIDs (p = 0.21). Condusions: Use of low-dose NS?dDs was not a ~ i a t e d with an increase in disease activity for these outpatients witfi either CD or UC, Use of high-dose NSA1Ds was associated with a higher level of disease activity among CD patients with colonic involvement.