Initial research on staging method of tumor deposits in CRC patients

Abstract

Objective To find a more appropriate staging method of tumor deposits. Methods We retrospectively evaluated patients with CRC, who underwent radical resection from March 1, 2007 to December 31, 2009 in Yunnan Province Cancer Hospital, data were collected retrospectively for statistical analysis. Results The prognosis of patients with TD were significantly worse than that of patients without TD in LNM patients (51.3% vs 74.9%, P=0.007). Multivariate Cox regression model analysis found that TD and postoperative adjuvant chemotherapy are independent risk factors for overall survival in LNM patients (P<0.05); TD which counted as positive lymph nodes with the new N staging system has better prognostic value for patients in each TNM stage (P<0.05). Multivariate analysis showed that TNM stage (nN) is still a prognosis factors, but the 7th edition of TNM stage system is not; The patients with TD were divided into two groups by the number of TD, and the prognosis was compared between two groups, results showed that only the group divided by TD=1 has significant difference in prognosis (31.2% vs 61%, P=0.018). Conclusions The staging method of tumor deposits in 7th edition TNM staging system is not appropriate for patients with lymph node metastasis. The prognostic value of a new TNM staging that counted TD as positive lymph nodes is better than 7th edition of TNM staging system, and the TNM staging system is simplified. Key words: Colorectal neoplasms; Prognosis; Staging; Tumor deposits