Abstract
The paper presents an assessment of treatment efficacy in chronic lymphocytic leukemia CLL patients according to chemotherapy type and initial renal function. The high efficacy of chemotherapy with fludarabine in CLL patients with or without renal failure at diagnosis was revealed. However, regardless of chemotherapy type initial treatment response was worse in patients with renal failure.
Highlights
Initial renal function and type of chemotherapy: impact on treatment efficacy in patients with chronic lymphocytic leukemia
Saraeva Irkutsk State Medical University; 1 Krasnogo Vosstaniya St., Irkutsk, 664003, Russia The paper presents an assessment of treatment efficacy in chronic lymphocytic leukemia CLL patients according to chemotherapy type and initial renal function
Regardless of chemotherapy type initial treatment response was worse in patients with renal failure
Summary
Initial renal function and type of chemotherapy: impact on treatment efficacy in patients with chronic lymphocytic leukemia. 1, у пациентов 1-й группы без почечной недостаточности в момент диагностики заболевания при лечении флударабинсодержащими схемами ХТ ответ наблюдался чаще, чем у пациентов этой же группы, получающих лечение без флударабина (83,3 % и 61,9 % соответственно), но различие статистически незначимо (р = 0,1). У пациентов 2-й группы с почечной недостаточностью в момент диагностики заболевания, получающих лечение флударабинсодержащими курсами ХТ, ответ наблюдался статистически значимо чаще, чем при лечении без флударабина (63,6 % и 19,6 % соответственно; р = 0,0007).
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