Abstract
AMONG the several temparature sensitive conditional mutants of the tetraploid cell line of African green monkey kidney (BS-C-1) is one (ts-2) in which simian virus 40 either fails to multiply or form tumour specific antigens (unpublished) at the temperature (39.5° C) at which cellular growth is restricted1. Because of the potential importance of this mutant in the study of host dependence of tumour virus multiplication, we have investigated several of its properties and have found that the mutant ts-2 is blocked in the incorporation of 3H-thymidine in the nucleus, probably in the nucleolus.
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