Inibina B (IB) e ormone Antimülleriano (AMH) quali indicatori di attività follicolare ovarica

Abstract

Inhibin B is a dimeric glycoprotein secreted by the granulosa cells of the small antral follicles; it is produced when the FSH levels are high enough to recruit follicles and to induce their maturation. Anti-Mullerian hormone in girls is express by granulosa cells and it plays an important role in follicles development by inhibiting the recruitment of primordial follicles into the pool of growing ones. AMH dosage has never been performed in girls with central precocious puberty. The aim of this study is to determine IB and AMH levels in girls with premature thelarche and central precocious puberty. We collected blood samples from 87 girls with premature thelarche, central precocious puberty before and during treatment with GnRH Analogous. The control group consisted of 26 healthy prepubertal girls. Inhibin B levels was higher in the majority of girls with premature thelarche and central precocious puberty before GnRH-A treatment; IB concentration was similar in girls whit central precocious puberty during GnRH-A treatment and controls. Inhibin B was significantly correlated to FSH, showing that its secretion is under gonadotropins control. Serum AMH levels are significantly lower in girls whit premature thelarche compared whit girls whit central precociuos puberty before (P=0.011) and during (P=0.037) treatment with GnRH-A. Serum AMH concentra-tions are not modify by GnRH-A treatment and there is not correlation between AMH levels and FSH or LH; there is a significant (r=0.24, P=0.0264) positive correlation between AMH and estradiol levels, showing the presence of ovarian follicular activity.