Abstract
The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. In this review article, we will outline the progression of understanding of receptor diffusion dynamics at the plasma membrane. We will discuss how regulation of reversible trapping of receptor-scaffold interactions in combination with theoretical modeling approaches can be used to quantify these chemical interactions at the postsynapse of living cells.
Highlights
Synaptic organization is a dynamic multiscale process in neuronal cell networks
Crick postulated that post-translational modifications of the molecules at the synapse could explain a longer-term persistent state of synaptic strength contributing to memory, despite a molecular turnover within days
This review will focus on the recent advances in our understanding of molecule dynamics in inhibitory synapses, covering technological advancements that have enabled probing of receptor and scaffold protein dynamics, organization and regulation
Summary
The dynamic modulation of receptor diffusion-trapping at inhibitory synapses is crucial to synaptic transmission, stability, and plasticity. We will outline the progression of understanding of receptor diffusion dynamics at the plasma membrane. We will discuss how regulation of reversible trapping of receptor-scaffold interactions in combination with theoretical modeling approaches can be used to quantify these chemical interactions at the postsynapse of living cells. Reviewed by: Enrica Maria Petrini, Italian Institute of Technology (IIT), Italy Jasmina N.
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