Inhibitory Potency of Selected Therapeutic Bioactive Molecules of Standardized Terminalia arjuna (Roxb.) Extract on CYP3A4 and CYP2D6: Exploring Possible Herb-Drug Interactions

Abstract

Context Picrorhiza kurroa Royle ex Benth (Scrophulariacae) is a small perennial herb distributed in the alpineHimalayan tract and in some tropical parts of India. The production of two compounds Phenyl tetraglucoside and Phenolic diglucoside bioactive in Picrorrhiza kurroa. It may suggest that it is containing an interesting bioactive compound. Aim This research aimed to characterize the new phenyl tetraglucoside and phenolic diglucoside compounds in Picrorrhiza species (kurroa sp.) found on the Himalayan and some tropical parts of India. Subjects and Methods Isolation of bioactive compounds through total methanol extracts. It has been done with spectral studies using thin layer chromatography. The structures of both compounds were elucidated on the basis of UV, IR, Nuclear Magnetic Resonance (H1 and C13 NMR) and Mass spectroscopic studies. Results Elucidation showed that compounds found as a new Phenyl tetraglucoside, namely, as 3-methoxy-4 hydroxyphenyl-n-butanyl-o-α-L-glucopyranosyl-(4a→1b)-α-L glucopyranosyl-(4b→1c)-α-L-glucopyranosyl-(4c→1d)-α-L-glucopyranosyl-4d-(3'-methoxy-4-hydroxyphenyl)-n-pent-7', 9'- dien-11'-oate, Phenolic diglucoside and vanillyl glucoside. Conclusion Results of this study suggest that a Picrorhiza kurroa species is a potential source of various active compounds.