Abstract
The inhibitory activity of a series of novel sugar-modified nucleosides derived from 5-benzyluracil, 5-phenylcytosine and 5-phenylpyrimidin-2-one against uridine phosphorylase purified from mouse leukemic L-1210 cells was investigated. Significant activity was encountered with O2,2′-anhydro-5-benzylcytidine hydrochloride, 2′,3′-dideoxy-5-benzyluridine, 2′,3′-dideoxy-4-thiouridine and α- and β-anomers of 5-benzyl-1-(2-deoxy-D-arabino-hexopyranosyl)uracil.
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