Abstract
1. 1. The inhibition of [ 3H]naloxone binding to the opioid receptor upon short-term incubation with phospholipase A 2 (Plase A 2) was abolished by treatment with BSA, but not after long-term incubation. 2. 2. In contrast to the restorative effect of BSA on the strong inhibition occurring with Plase A 2, BSA only partially abolished the inhibitory effect of arachidonic acid or lysophosphatides, even though the degree of inhibition was slight. 3. 3. These results suggest that Plase A 2 products only become associated with hydrophobic receptor sites or with phospholipids near to the receptor, thus reversibly inhibiting opioid binding, and that irreversible inhibition occurs through release of the phospholipid necessary for receptor binding.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
