Abstract
The effects of genistein and erbstatin analogue, inhibitors of tyrosine kinase, on Ca 2+ mobilization evoked by thapsigargin (TG) were examined in rat glioma C6 cells. Genistein and erbstatin analogue inhibited the Ca 2+ release from intracellular pools as well as Ca 2+ entry from extracellular medium evoked by TG in a dose-dependent manner. However, they did not affect a Ca 2+ entry due to leakage of Ca 2+ from extracellular medium into cells. The present results suggest that tyrosine kinase inhibitors inhibit capacitative Ca 2+ entry due to the inhibition of both Ca 2+ entry itself and Ca 2+ release in rat glioma C6 cells.
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