Abstract
Studies have shown that increased consumption of fruits and vegetables reduce risk for developing a number of chronic diseases including cardiovascular disease, cancer and diabetes. Recent studies have suggested that increased risk for these diseases may be due to increased inflammatory responses. Furthermore, tart cherry has been shown to decrease cancer incidence and inflammatory factor expressions. Thus, we hypothesized that tart cherry inhibit IL-6 and CRP levels. To address our hypothesis, we treated 3T3-L1 preadipocytes, in vitro, with increasing concentration of frozen tart cherry and tart cherry powder extracts. Results showed that both frozen tart cherry and tart cherry powder extracts significantly inhibit 3T3-L1 preadipocytes in a dose dependent manner (p<0.05). We further tested in vivo effects of tart cherry by feeding tart cherry powder (10g/100g diet) to lean (C57Bl/6J) and leptin deficient obese (ob/ob) mice for 1 month. Results showed that tart cherry inhibit hepatic CRP mRNA and adipose IL-6 mRNA levels in both lean and ob/ob mice. Taken together, these data suggest that tart cherry have anti-inflammatory effects by inhibiting adipose tissue (IL-6) and hepatic (CRP) inflammatory factor mRNA synthesis.
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