Abstract
As part of efforts to discover phytochemicals that inhibit melanin biosynthesis, we screened (E)-2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) isolated from Polygonum multiflorum. THSG dose-dependently inhibited tyrosinase activity, with an ID50 value of 100 μg/mL. THSG also potently inhibited melanin production in B16 melanoma cells induced by forskolin, an inducer of melanogenesis, with ID50 of 1–10 μg/mL. THSG may therefore reduce melanogenesis.
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