Abstract
Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.
Highlights
Epstein-Barr virus (EBV) is a gamma-herpesvirus, which infects human lymphoid cells and epithelial cells [1]
Resveratrol inhibit the expression of viral lytic proteins
Resveratrol was added to P3HR1 cells (3 × 106) that had been treated with sodium butyrate to activate the EBV lytic cycle
Summary
Epstein-Barr virus (EBV) is a gamma-herpesvirus, which infects human lymphoid cells and epithelial cells [1]. At the onset of the lytic cycle, EBV expresses two transcription factors, Rta and Zta, which are transcribed from BRLF1 and BZLF1, respectively [7]. These two proteins trigger an ordered cascade of the expression of viral lytic genes, including that of BMRF1 and BALF5, which encode diffused early antigen (EA-D) and DNA polymerase [8]. The purpose of our study was to evaluate whether resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and viron production
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