Abstract
Alcohol, coffee, salty and spicy foods, excessive acid secretion, and NSAIDs increase risk of having a gastritis. Helicobacter pylori (H. pylori), in particular, is known to be a pathogen that is capable of causing gastritis and gastric cancer. Reactive oxygen species and oxidative stress may also play a role as a major factor in gastric injury. In this study, we studied extracts of Polygala tenuifolia Willd. (root), Polygala japonica and Polygala tenuifolia (sprout) for their inhibitory effects on HCl·ethanol-induced gastritis in rats. As a result, extracts showed 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity, reducing power, inhibitory effect on H. pylori colonization and acid-neutralizingcapacity. Especially, the extracts of Polygala tenuifolia Willd. and Polygala japonica significantly inhibited HCl·ethanol-induced gastritis in rat. The results obtained indicate that these extracts might be useful for preventing gastritis.
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