Abstract
(1) The effects of phenylhydrazine treatment on both tryptophan pyrrolase activity in intact and adrenalectomized rats and the inducible response of the enzyme to the hormone and the substrate in adrenalectomized rats were investigated. (2) The administration of phenylhydrazine in intact rats as well as adrenalectomized rats resulted in increase in the level of tryptophan pyrrolase. (3) No effects of phenylhydrazine on tryptophan pyrrolase was observed in rats which were induced by administration of glucocorticoid. (4) The induction of the enzyme by the substrate was depressed significantly when phenylhydrazine was administered during 4-24 h before sacrifice. (5) Suppressive effects of phenylhydrazine on the tryptophan-induced enzyme activity seems to be associated with the disturbance of porphyrin metabolism in rats.
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