Abstract
In the differentiation of a 3T3-L1 preadipocyte to a mature adipocyte, intensive triglyceride (TG) synthesis and intracellular accumulation of lipid droplets are induced. Lupeol, a lupane triterpene, markedly blocked TG synthesis and the accumulation of lipid droplets in 3T3-L1 cells stimulated with differentiation inducers. The analysis of gene expressions by quantitative real-time RT-PCR demonstrated that lupeol markedly inhibited adipogenic transcription factors, adipogenic enzymes, and adipocytokines in mature 3T3-L1 cells. These findings suggested that lupeol strongly inhibited 3T3-L1 cell differentiation into mature adipocytes in vitro.
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