Inhibitory Effects of Gallic Acid Isolated from Caesalpinia mimosoides Lamk on Cholangiocarcinoma Cell Lines and Foodborne Pathogenic Bacteria.

Narintorn Rattanata,Ratree Tavichakorntrakool,Patcharee Boonsiri,Ratsami Lekphrom,Temduang Limpaiboon,Sakda Daduang,Jureerut Daduang,Sompong Klaynongsruang

doi:10.7314/apjcp.2016.17.3.1341

Narintorn Rattanata, Ratree Tavichakorntrakool + Show 6 more

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https://doi.org/10.7314/apjcp.2016.17.3.1341

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Abstract

Gallic acid was isolated from Caesalpinia mimosoides Lamk and the structure s identified based on spectroscopic analysis and comparison with authentic compound. In this study we compared the ability of natural gallic acid (nGA) and commercial gallic acid (cGA) to inhibit the proliferation of cholangiocarcinoma cell lines (M213, M214) and foodborne pathogenic bacteria (Salmonella spp. and Plesiomonas shigelloides). Both nGA and cGA had the same inhibitory effects on cell proliferation by inducing apoptosis of cholangiocarcinoma cell lines. In addition, nGA inhibited growth of foodborne pathogenic bacteria in the same manner as cGA. Our results suggest that nGA from Caesalpinia mimosoides Lamk is a potential anticancer and antibacterial compound. However, in vivo studies are needed to elucidate the specific mechanisms involved.

Highlights

Cancer and diarrheal diseases are major causes of mortality in developing countries (WHO, 2012)
In this study we compared the ability of natural gallic acid and commercial gallic acid to inhibit the proliferation of cholangiocarcinoma cell lines (M213, M214) and foodborne pathogenic bacteria (Salmonella spp. and Plesiomonas shigelloides)
This study examines the beneficial effects of phytochemicals from C. mimosoides Lamk, including anticancer activity towards cholangiocarcinoma cell lines and antimicrobial effects on the foodborne pathogenic bacteria Salmonella spp. and Plesiomonas shigelloides

Summary

Introduction

Cancer and diarrheal diseases are major causes of mortality in developing countries (WHO, 2012). Bacterial foodborne illnesses are a common problem worldwide, including those caused by Salmonella spp. and Plesiomonas shigelloides. Bioactive compounds from plant phytochemicals could be a potential source for effective drugs as well as food supplements and nutraceuticals. Extensive experimental works over the past decade have identified beneficial effects of C. mimosoides Lamk related to its antimicrobial activities (Chanwitheesuk et al, 2007; Daduang et al, 2011), antioxidant activities (Chanwitheesuk et al, 2005), anti-inflammatory activities (Yodsaoue et al, 2010), and neuroprotective effects (Tangsaengvit et al, 2013). This study examines the beneficial effects of phytochemicals from C. mimosoides Lamk, including anticancer activity towards cholangiocarcinoma cell lines and antimicrobial effects on the foodborne pathogenic bacteria Salmonella spp. and Plesiomonas shigelloides

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