Abstract
Fucoxanthin was shown to inhibit chemical carcinogenesis. Fucoxanthin is a natural carotenoid prepared from brown algae which is an ingredient used daily in Japanese food. In this study, all mice were given 0.01 % N-ethyl-N′-nitro-N-nitrosoguanidine in their drinking water for 4 weeks. This was followed by 0.005% fucoxanthin in dimethylsulfoxide or the vehicle alone in the drinking water. In the 16-week fucoxanthin-treated group both the percentage of tumor-bearing mice and the average number of tumors per mouse were significantly lower than those of the control group. The results indicate that fucoxanthin inhibited duodenal carcinogenesis induced by N- ethyl-N′-nitro-N-nitrosoguanidine in mice.
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