Abstract
Background: Sweet potatoes (Ipomoea batatas L.) with purple, orange and white varieties can be differentiated by their skin and flesh tubers’ colors. Research on anti-inflammatory activity of this plant is still limited although has been used traditionally. Objective: This study aimed to determine IC50 value of sweet potato tubers extracts in inhibiting lipoxygenase activity. Methods: Dried tubers of sweet potato were macerated with ethanol 70%. Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents. IC50 value and total flavonoid contents obtained from each extracts were analyzed statistically. Results: IC50 value of purple, orange and white sweet potato tubers extracts are 46.09, 52.12 and 63.69 μg/mL respectively. Each extracts contain alkaloids, flavonoids, saponins, tannins and glycosides. Total flavonoid contents in purple, orange and white sweet potato extracts are 8.45±0.41; 7.57±0.03; and 6.12±0.14 mgQE/g extract respectively. Conclusion: Total flavonoid contents and IC50 values of each extracts are strongly correlated and inversely proportional with significance value of 0.026 and correlation value of -0.999 which indicate that the higher total flavonoid contents, the stronger inhibitory activity.
Highlights
Over the past few decades, researches for medicines derived from plants has been widely carried out
Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents
The extract used in this study was produced from the simplicia of sweet potato tuber (Ipomoea batatas L.) with varieties of purple, orange and white obtained from Depok, West Java, Indonesia
Summary
Over the past few decades, researches for medicines derived from plants has been widely carried out. Ipomoea batatas L., commonly known as sweet potato, is root vegetable which is often consumed as food.[1] The value of production and consumption of sweet potato in Indonesia in 2016-2019 is growing every year. Sweet potatoes (Ipomoea batatas L.) with purple, orange and white varieties can be differentiated by their skin and flesh tubers’ colors. Objective: This study aimed to determine IC50 value of sweet potato tubers extracts in inhibiting lipoxygenase activity. Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents. IC50 value and total flavonoid contents obtained from each extracts were analyzed statistically. Results: IC50 value of purple, orange and white sweet potato tubers extracts are 46.09, 52.12 and 63.69 μg/mL respectively. Total flavonoid contents in purple, orange and white sweet potato extracts are 8.45±0.41; 7.57±0.03; and 6.12±0.14 mgQE/g extract respectively. Conclusion: Total flavonoid contents and IC50 values of each extracts are strongly correlated and inversely proportional with significance value of 0.026 and correlation value of -0.999 which indicate that the higher total flavonoid contents, the stronger inhibitory activity
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