Abstract
The water extract of Juglans mandshurica fruit has been shown to strongly inhibit pancreatic lipase in vitro in a dose-dependent manner. The extract was observed to inhibit the normal elevation in the level of plasma triacylglycerol in rats 2–4 h after oral administration of a lipid emulsion. Fourteen compounds isolated from J. mandshurica fruit were evaluated for their inhibitory activity against pancreatic lipase. Of these, 1,4,8-trihydroxynaphthalene-1-O-β-d-[6′-O-(3″,4″,5″-trihydroxybenzoyl)]glucopyranoside (1) showed the strongest inhibitory activity.
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