Abstract
The anti-pruritic mechanisms of azelastine were studied in mice. Scratching induced by intradermal histamine was inhibited by azelastine (30 mg/kg) and chlorpheniramine (30 mg/kg). Substance P-induced scratching was dose dependently suppressed by azelastine (3–30 mg/kg), but not by chlorpheniramine (10 and 30 mg/kg). Azelastine (30 mg/kg) inhibited the substance P-induced production of leukotriene B 4, but not prostaglandin E 2, in the skin. Azelastine (3–30 mg/kg) suppressed scratching induced by intradermal injection of leukotriene B 4. The results suggest that inhibition of the production and action of leukotriene B 4, as well as an anti-histamine action, is involved in the anti-pruritic action of azelastine.
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