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Abstract
Objective To investigate the inhibiting effects of 5-fluorouracil magnetic albumin microsphere (5-FU-MAMS) in combination with constant external magnetic fields on human pancreat-ic carcinoma in vitro and in vivo. Methods The human pancreatic carcinoma PC-3 cells were cultured and an experimental model was established in nude mice to investigate the inhibiting effects. Results In vitro study showed that 5-FU-MAMS in combination with constant external magnetic fields could significantly inhibit the growth of PC-3 ceils as compared with other agents (P＜0.05). The in vivo study revealed that 5-FU-MAMS could be well localized in the tumor tissue and markedly inhibit the growth of tumor. The inhibitory rate of tumor size was 90.47% and that of tumor weight 88. 16%.There were significant differences as compared with other groups (P＜0.05). Conclusion Under con-stant external magnetic fields, 5-FU-MAMS can achieve satisfactory results for targeted therapy of pancreatic carcinoma. Key words: Pancreatic neoplasms; 5-FU-MAMS; Targeted therapy
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