Abstract
Dermatophytosis is a serious fungal infection of superficial keratinized tissue in man and animal. At least one million people in India were suffering from this infection. Present investigation deals with the screening and study of 6 major compounds of essential oils like myrcene, linalool, citral, geraniol, limonene and citronellol against Candida albicans, Microsporum gypseum, M. canis and Trichophyton rubrum. The minimum inhibitory concentration was determined through semi-solid agar antifungal testing methods. Among all these compounds geraniol and citronellol exhibited excellent antidermatophytic activities. MIC of geraniol was ranged from 0.025 μL/mL to 0.1 μL/mL. MIC of citronellol was obtained > 0.012 μL/mL to 0.1 μL/mL concentrations. MIC of citral was ranged from 0.05 μL/mL to 0.2 μL/mL. Linalool also showed strong antifungal behavior against all tested microorganisms. Myrcene and limonene were found to be very less effective compounds as compared to others. M. canis was found to be resistant from both myrcene and limonene.
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