Inhibitory effect of Solanum anguivi fruit extracts against lead-induced lipid peroxidation in rat liver and kidney

Abstract

Rapid incidence of liver and kidney disorders resulting in high mortality nowadays is of great concern and there is this very need to salvage the sudden death resulting from the disorders. Lipid peroxidation which is the hallmark of oxidative stress that damage body tissues is prominent as one of the causative factors leading to many chronic and degenerative diseases. This study is sought to investigate the inhibitory effect of aqueous and ethanolic extracts of Solanum Anguivi fruit against lead acetate induced lipid peroxidation in the liver and kidney tissues of albino rats in vitro using thiobarbituric acid reactive substances (TBARS) assay. The results obtained indicate a concentration dependent increase in inhibitory potential of the extracts against lead acetate in both liver and kidney tissues. Highest extract inhibitory potential was (90%) at highest extract concentration (160mg/ml) and this was obtained in the liver tissue. Hence, the results from this study suggest that oxidative stress in liver and kidney tissues could be potentially prevented or managed by dietary intake of Solanum Anguivi fruits.