Abstract
As a part of our ongoing research to find novel functions in mango leaves, we have reported that the methanolic extract of pruned old dark green mango leaf (Mangifera indica ‘Irwin’) exhibited inhibitory effects on the formation of advanced glycation end products (AGEs) in nonenzymatic glycation of albumin. The purpose of this study was to find other mango cultivars with more potent activity in this regard. We examined the inhibitory effect of seventeen mango (Mangifera indica) cultivar leaf extracts on AGEs formation. We also investigated the relationship between the inhibitory activity of the extracts and the contents of their active components, 3-C-β-D-glucosyl-2,4,4’,6-tetrahydroxybenzophenone (1), mangiferin (2) and chlorophyll (3). On the basis of the evaluation of the inhibitory activity of mango cultivar leaf extracts, the HPLC determination of the contents of 1 and 2, and the spectrophotometric determination of 3, it was found that almost all extract showed a significant activity, and the content of 2 and 3 detected in each was similar. In contrast, AGEs formation inhibition tended to be higher as the content of 1 in the leaf extracts increased. This is the first report of phytochemical analysis of compounds 1, 2 and 3 in various cultivars of mango leaf. From the phytochemical point of view, these results suggest that the pruned leaves of any cultivar of Mangifera indica except ‘Chiin Hwang No. 1’ and ‘Kyo Savoy’ may be useful for the preparation of natural ingredients with inhibitory activity of AGEs formation.
Highlights
Tropical and subtropical fruits are highly valued owing to their nutritional benefits as well as for the presence of health-promoting ingredients
As a part of our ongoing research to find novel functions in mango leaves, we have reported that the methanolic extract of pruned old dark green mango leaf (Mangifera indica „Irwin‟) exhibited inhibitory effects on the formation of advanced glycation end products (AGEs) in nonenzymatic glycation of albumin
We have previously reported that the methanolic extract of pruned old dark green mango (Mangifera indica „Irwin‟) (OML-ext) exhibited inhibitory activity of AGEs formation in nonenzymatic glycation of albumin (Itoh et al, 2017)
Summary
Tropical and subtropical fruits are highly valued owing to their nutritional benefits as well as for the presence of health-promoting ingredients. (mango) is considered as “the king of fruits” because it is the most popular fruit in the tropical regions (Lauricella, Emanuele, Calvaruso, Giuliano, & D‟Anneo, 2017). It is the national fruit of India and the Philippines, and M. indica is the national tree of Bangladesh (Usman, Fatima, & Jaskani, 2001). The mango is native to India and Southeast Asia where it has been cultivated for at least 4000 years and over 1000 cultivars are recognized (Mukherjee, 1953). The cultivation of mango gradually spread to tropical and subtropical countries throughout the world, where selections to adapt the plants to specific growth conditions were made. Human selection has played the most significant role in the development of new http://jps.ccsenet.org
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