Abstract
It is suspected that pentachlorophenol (PCP), used as an organochlorine herbicide, has toxicity related with the lipid peroxidation. The lipid peroxidation by the in vitro metabolism of PCP in a microsomal system was inhibited by riboflavin tetrabutyrate (B2-But), a fat-soluble riboflavin, but not inhibited by water-soluble flavins. The lipid peroxidation in the liver of mice exposed to 35 μmol/kg of PCP was suppressed by the simultaneous administration of B2-But, but scarcely suppressed by other flavins. Moreover, the changes of mitochondrial ADP/O ratio and flavin contents in the liver of mice were also suppressed by B2-But. It was considered that the suppressive effect of B2-But on the liver injury by PCP due to the inhibition of the lipid peroxidation and the flavin supply by B2-But in the liver.
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