Abstract
The effects of okadaic acid (30 μM), a protein phosphatase inhibitor, on noradrenaline (NA) release evoked by 70 mM KCl and 100 μM ouabain were evaluated in guinea-pig vas deferens. Release of NA evoked by high KCl was inhibited by okadaic acid but this inhibition was antagonized by Bay K 8644. Furthermore, okadaic acid, like Ca 2+-channel blockers, reduced NA release by ouabain. However, ATP release induced by α,β-methylene ATP was virtually unaffected by okadaic acid or Ca 2+-free medium. These findings suggest that phosphatases may play an important role in Ca 2+-channel activation and consequent NA exocytosis from adrenergic nerves.
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