Inhibitory effect of novel red ginseng treated with high temperature and high pressure on oxidative damage

Abstract

Ginseng is one of the most commonly used traditional herbal medicines. This study was to investigate the inhibitory effect of novel red ginseng treated with high temperature and high pressure in oxidative stress‐induced mouse by high intensity exercise. Experimental groups were no exercise group(CON), high‐intensity exercise group(E), common red ginseng extract supplementation with high‐intensity exercise group(CGE), novel ginseng red extract supplementation with high‐intensity exercise group(NGE). High‐intensity exercise was performed by treadmill running for two weeks. After the experimental period, changes of glutamic pyruvic transaminase(GPT) and glutamic oxaloacetic transaminase(GOT) in serum was measured, and MDA levels, glycogen contents, glucose‐6‐phosphate dehydrogenase(G6PDH), lactate dehydrogenase(LDH) activities and gene expressions of Cu/Zn SOD and myogenic factor4(MRF4) on tissue were analyzed. Our results show that the levels of GOT, GPT and MDA in NGE group were significantly lower than those of other groups. Moreover, the levels of muscular glycogen, G6PDH activity, LDH activity of NGE group were markedly higher than those of other groups. In the case of gene expression on muscle tissue, CGE or NGE groups led to up regulation of SOD and MRF4 gene expression. These results indicate that NGE can inhibit high‐intensity induced oxidative stress and enhance exercise capacity.