Abstract
PURPOSE: To investigate the inhibitory effects of losartan, an angiotensin receptor antagonist, on angiogenesis in a rat model of laser-induced choroidal neovascularization. METHODS: Experimental study. Fifteen Brown–Norway male rats received losartan (approximately 5 mg/kg/d) in drinking water, and 15 Brown–Norway male rats received unsupplemented drinking water 1 week before photocoagulation, and it was continued to the end of the study. Two weeks after intense laser photocoagulation, choroidal neovascularization was evaluated by fluorescein angiography and histopathologic evaluation. RESULTS: The incidence of choroidal neovascularization formation was 99.5 ± .2% (mean ± standard deviation) in controls and 72.5 ± 8.8% in losartan-treated rats ( P < .01). Quantitative morphometric assessment revealed mean choroidal neovascularization lesion thickness of 54 and 44.8 μm, respectively, in controls and losartan-treated rats ( P < .01). CONCLUSION: Losartan seems to inhibit development of laser-induced choroidal neovascularization. Angiotensin receptor antagonists may be useful as prophylaxis against choroidal neovascularization associated with age-related macular degeneration.
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