Abstract
Ibuprofen was found to be slightly more active than acetylsalicyclic acid (ASA) as an inhibitor of collagen-induced platelet aggregation in human and rat PRP. This inhibition was demonstrable only while the drug was present in the plasma. It did not inhibit thrombin-induced aggregation but inhibited the second wave of ADP and epinephrine-induced platelet aggregation. It inhibited arachidonic acid-induced aggregation at much lower concentrations than those required to inhibit collagen-induced aggregation. The release of radioactivity from platelets prelabeled with 3H-serotonin as well as the oxygen-burst were inhibited by the compound when platelets were stimulated with collagen. The compound was found to be orally active in reducing the number of deaths in mice following injection of collagen suspension and it inhibited platelet aggregation after oral administration of 10 mg/kg to rats.
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