Abstract
Earlier studies showed that high dietary zinc interfered with copper absorption at the intestinal level. The data presented here demonstrated that there was a significant decrease in copper content with a concomitant increase in zinc content of the intestinal segment of the zinc-fed rats. Gel filtration analysis on Sephadex G-75 of the cytosol fraction from the mucosa of the zinc-fed rats demonstrated that major parts of zinc in the cytosol bind to the protein with a molecular weight of about 10000, that is, the zincthionein. The simultaneous administration of copper and zinc to the normal rats also caused an incorporation of copper into this protein. These results suggested that the interference of copper absorption by zinc may be due to the inductive effect of zinc on the synthesis of the zinc-thionein, which sequesters copper available for absorption.
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