Abstract
Anticancer activity of many herbs was observed for hundreds of years. They act as modifiers of biologic response, and their effectiveness may be increased by combining multiple herbal extracts . PERVIVO, traditional digestive herbal remedy, contains some of them, and we previously described its antiangiogenic activity. Numerous studies documented anticancer effects of nonsteroidal anti-inflammatory drugs. We were the first to show that sulindac and its metabolites inhibit angiogenesis. In the present paper the combined in vivo effect of multicomponent herbal remedy PERVIVO and nonsteroidal anti-inflammatory drug sulindac on tumor growth, tumor angiogenesis, and tumor volume in Balb/c mice was studied. These effects were checked after grafting cells collected from syngeneic sarcoma L-1 tumors into mice skin. The strongest inhibitory effect was observed in experimental groups treated with PERVIVO and sulindac together. The results of our investigation showed that combined effect of examined drugs may be the best way to get the strongest antiangiogenic and antitumor effect.
Highlights
Tumor angiogenesis, the development of new blood vessels within the primary tumor or in metastasis hotspots, is an essential process for the growth and progression of metastases
The dominant picture was mass of poorly differentiated atypical cells with features of sarcoma
The influence of the study drugs on measurable tumor emergence in respective days after sarcoma load inoculation is shown in Figure 3 and Table 3
Summary
The development of new blood vessels within the primary tumor or in metastasis hotspots, is an essential process for the growth and progression of metastases. Both innate and adaptive immune systems are involved in positive and negative regulations of this process. Despite the discovery of many such agents, the need for further research exists, because the angiogenesis inhibitors obtained so far are either very costly to synthesize, or they exhibit a number of side effects. The need to recourse to low-toxic vegetal compounds and studies of combined effects of a few low-dosage compounds with different modes of action on the processes of angiogenesis in Mediators of Inflammation tumor growth. Many phytochemicals and diet derivatives are able to exert chemopreventive and antitumor activity targeting the tumor environment and inflammatory angiogenesis [1,2,3]
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