Abstract
Problem statement:The fungal infections could be life-threatening in immunocompromised patients. Candida albicans is the most frequent fungi in the oral cavity. Approach: The first step for treatment could be done using topical antifungal agents. Nystatine is a choice for mentioned usage but there are some problems in its using including: unfavorite taste, frequency of usage, etc. Finding better replacements is the subject of many studies. Results: This study was carried out to find an alternative for Nystatine. The study was designed based on laboratory investigations to investigate the antifungal activity of zingiber offcinale (Ginger) on Candida albicans. Candida albicanse (PTCC 5027, ATCC10231) was obtained from Iranian microbial collection and was confirmed by Germ Tube formation test. Ethanolic ginger extract was prepared. The antifungal activity of the extract was determined using Agar dilution and disc diffusion techniques. Data were analyzed by ANOVA test. Conclusion/Recommendations:The results showed that the ethanolic extract was effective on Candida albicans (2 mg mL-1) at the concentration of 1:5. The study indicates that ginger extract might have promise in treatment of oral candidiasis.
Highlights
The incidence of serious infections caused by yeast, species of Candida, has increased dramatically during the past decade
The ginger extract was effective in inhibiting the growth of Candida albicanse
Minimum Inhibitory Concentration (MIC) of the ginger extract was obtained for the concentration at 2 mg mL−1 (1:5 dilution)
Summary
The incidence of serious infections caused by yeast, species of Candida, has increased dramatically during the past decade. There are topical and systemic antifungal agents that may be indicated to control oral candidiasis, but, the development of resistance is an emerging trend that may threaten their clinical effectiveness[1,2,3,4]. Safety and lower side effects of many herbal extracts have suggested them as sources of new pharmaceuticals[5,6,7,8]. History of ginger and its applications are well documented[9,10]. It has been in medical use since ancient times. More recently studies have shown the antifungal properties of ginger extract, Gingerol[13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
