Abstract
To search for possible anti-tumor promoters, ten flavonoid derivatives ( 1– 10) synthesized from morin and quercetin were examined for their inhibitory effects on the Epstein–Barr virus early antigen (EBV-EA) activation by a short-term in vitro assay. Of these compounds, pentaallyl ethers ( 9, 10) showed significant inhibitory effects on EBV-EA activation induced by the tumor promoter, 12- O-tetradecanoylphorbol 13-acetate. Further, quercetin pentaallyl ether ( 10) exhibited remarkable inhibitory effects on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test.
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