Abstract
Administration of bleomycin (1 mg/rat/day) for 5 days into granuloma pouch resulted in significant increase of intercellular substances of the granulomatous tissue measured at the 5th day from the last injection of bleomycin, i.e., 130% for collagen, 261% for nonsulfated glycosaminoglycan, 129% for sulfated glycosaminoglycan and 153% for glycoprotein, while no significant alteration was observed in desoxyribonucleic acid and ribonucleic acid contents. The increment of these macromolecules caused by bleomycin treatment was inhibited by successive administration of D-penicillamine (60 mg/rat/day) for 5 days.
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