Abstract
Cycloheximide administered to rats in non-toxic doses immediately after pyloric ligation results in a lower incidence of experimental gastric ulcers. The effect is paralleled by an impaired secretion of hydrochloric acid (more than 90 per cent inhibition). Simultaneously the activity of pepsin in gastric juice and in homogenates of gastric mucosa was reduced by 60 per cent and mucoproteins were lowered by 30 per cent. The basal and pentagastrin-stimulated secretion were inhibited by cycloheximide to the same extent.
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