Abstract
The inhibitory effect of curcumin on the Cu(Ⅱ) and Zn(Ⅱ)-induced conformation transition of silk fibroin(SF) as a model protein of neurodegenerative diseases,was investigated for aiming at investigating the potency of curcumin in the prevention and treatment of neurodegenerative diseases.The results indicate that curcumin can inhibit Cu(Ⅱ) and Zn(Ⅱ)-induced conformational transition of SF through chelating Cu(Ⅱ) and Zn(Ⅱ),meanwhile,Cu(Ⅱ)-curcumin complex also has ability to inhibit the conformation transition of SF,but Zn(Ⅱ)-curcumin complex does not.Therefore,based on those results about the effective interference of curcumin on Cu(Ⅱ) and Zn(Ⅱ)-induced conformation transition of SF,curcumin could be suggested as a potential agent for the prevention and treatment of neurodegenerative diseases.
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