Abstract
C-reactive protein (CRP) was found to inhibit the phospholipase D activity significantly with dose dependency. Addition of 15 μg/ml CRP resulted in about 60 % decrease in phospholipase D activity using phosphatidylcholine dispersed with Triton X-100 as substrate. and more using lipid suspension consisting of only phosphatidylcholine. In Lineweaver- Burk analysis with phosphatidylcholine dispersed with Triton X-100, the apparent Km value of phospholipase D for phosphatidylcholine increased from 2.27 mg/ml to 3.72 mg/ml by addition of 7.5 μ g/ml CRP whereas the V max value was not altered. The possible usefulness of CRP as phospholipase D inhibitor was discussed.
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