Abstract
Typhoid Fever is a systemic disease which is more prevalent in under-developed countries. Drug resistance has been developed against antibiotics used for the treatment of typhoid. It is very important to set the basis of alternative medicines for management of typhoid. Garlic is one of the natural plants being used as spicy food and folk medicine. Various beneficial therapeutic effects of garlic have been documented including anti-microbial, hypolipodemic and anti-oxidant. The objective of present study was to explore anti-bacterial activity of aqueous garlic extract against Salmonella typhi. A total of 50 clinical isolates of S. typhi including 30 multi-drug resistant (MDR) and 20 antibiotic sensitive isolates were investigated to check the inhibitory effects of garlic extract; screening was done by agar well diffusion assay and minimal inhibitory concentration (MIC) was performed by agar dilution technique. MIC of garlic extract ranged from 18-22 mg/ml; showing the inhibitory activity of garlic extract against S. typhi isolates. It is worth describing that garlic might be utilized as anti-typhoid agent after determining its pharmacokinetics and pharmacodynamics.
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