Abstract
To find an effective chemotherapy for preventing liver metastasis of cancer cells through the circulating blood, Mitomycin C (MMC), Chromomycin A3 (CMA3) and nitrogen mustard N-oxide (NMO) were tested for the effect on the incidence of liver metastasis in C3H or (C3Hxdd) F1 mice intraportally inoculated with the ascites hepatoma MH-134. All these chemotherapeutics, administered via the spleen or into the abdominal cavity, exhibited appreciable inhibitory effects on the formation of metastasis and the life spans of the recipients were considerably prolonged. The effect was most remarkable when MMC was intraperitoneally given three times: immediately after inoculation, 24 hours later and 72 hours later; in this case 37.5 per cent of the animals survived more than 100 days and the incidence of liver metastasis was 50.0 per cent, whereas the tumor killed the untreated mice within 28 days with 100 per cent incidence of liver metastasis. NMO was almost comparable in effect to MMC, but CMA3 appeared to be some-what less effective.
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