Abstract
BackgroundOur previous studies have demonstrated that Ang II induced IGF-II and IGF-II R via ERK and JNK signaling pathways and further induces cardiac cell apoptosis. PurposeThe present study investigates the protective role of alpinate Oxyphyllae fructus (AOF; Alpinia oxyphylla Miq) extracts on angiotensin II (Ang II)-stimulated H9c2 cardiomyoblast cells. MethodsWestern blotting was used to analyze the molecular mechanism involved in Ang II-treated H9c2 cells. ResultsAOF inhibits cardiac hypertrophy, apoptosis, mitochondrial dysfunction, and cardiac remodeling in Ang II-treated H9c2 cells. ConclusionAll these data collectively suggest us that, AOF significantly inhibits Ang-II induced H9c2 cells apoptosis by suppressing the mitochondrial apoptotic pathway.
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