Abstract
Surface pre-reacted glass-ionomer (S-PRG) filler is a bioactive functional glass that releases six different ions. Although several dental materials containing S-PRG filler have been developed, few self-care products containing S-PRG filler have been reported. We investigated the inhibitory effects of PRG gel paste containing S-PRG filler on Streptococcus mutans, a major pathogen of dental caries. PRG gel paste inhibited bacterial growth of S. mutans in a concentration-dependent manner, and all S. mutans were killed in the presence of ≥ 1% PRG gel paste. Additionally, it was difficult for S. mutans to synthesize insoluble glucan from sucrose in the presence of 0.1% PRG gel paste. A biofilm formation model was prepared in which slices of bovine enamel were infected with S. mutans after treatment with or without PRG gel paste. Biofilm formation was inhibited significantly more on the enamel treated with PRG gel paste than on enamel without PRG gel paste (P < 0.001). The inhibitory effects on bacterial growth and biofilm formation were more prominent with PRG gel paste than with S-PRG-free gel paste, suggesting that PRG gel paste may be effective as a self-care product to prevent dental caries induced by S. mutans.
Highlights
Dental caries is still the most common infectious disease in the w orld[1]
The inhibitory effect of PRG gel paste on the bacterial growth of S. mutans MT8148, which was added to brain heart infusion (BHI) broth at a concentration of 1.0 × 1 07 CFU/ml, was chronologically examined
After 6 h, almost all S. mutans were killed by 1% PRG gel paste, and the bacterial growth of S. mutans was inhibited by 0.1% PRG gel paste (Fig. 1B)
Summary
Dental caries is still the most common infectious disease in the w orld[1]. Recently, poor oral health has been recognized as being closely associated with quality of life[2, 3]. S-PRG filler has some beneficial functions for maintaining oral health, such as anti-plaque formation, acid neutralization, and enamel remineralization[11,12,13]. Ions released from S-PRG eluate, which was the supernatant after mixing S-PRG filler with sterile distilled water, could inhibit bacterial growth and biofilm formation of Streptococcus mutans, a major pathogen of dental caries[14]. The effect of PRG gel paste on bacterial growth and biofilm formation induced by S. mutans remains unknown. The inhibitory effect of PRG gel paste on the major cariogenic properties of S. mutans was analyzed using in vitro assays to assess bacterial growth and glucan synthesis. The effect of PRG gel paste on biofilm formation by S. mutans was evaluated after PRG gel paste was applied to the surface of bovine enamel test pieces
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