Abstract
Neural circuits in the basolateral amygdala (BLA) play a pivotal role in the learning and memory formation, and processing of emotionally salient experiences, particularly aversive ones. A diverse population of GABAergic neurons present in the BLA orchestrate local circuits to mediate emotional memory functions. Targeted manipulation of GABAergic neuronal subtypes has shed light on cell-type specific functional roles in the fear learning and memory, revealing organizing principles for the operation of inhibitory circuit motifs in the BLA.
Highlights
Classical anatomical studies by Cajal and Golgi shed light on the morphological diversity of neurons in the brain
We review the diversity of GABAergic neurons and their local circuits in the rodent basolateral amygdala (BLA), a mid-temporal lobe structure that
Dysfunctions within BLA circuits are thought to contribute to a host of anxiety-like disorders such generalized anxiety and posttraumatic stress (Perumal et al, 2018)
Summary
Neural circuits in the basolateral amygdala (BLA) play a pivotal role in the learning and memory formation, and processing of emotionally salient experiences, aversive ones. A diverse population of GABAergic neurons present in the BLA orchestrate local circuits to mediate emotional memory functions. Targeted manipulation of GABAergic neuronal subtypes has shed light on cell-type specific functional roles in the fear learning and memory, revealing organizing principles for the operation of inhibitory circuit motifs in the BLA. Reviewed by: Haijiang Cai, University of Arizona, United States Gabrielle Girardeau, INSERM U839 Institut du Fer à Moulin (IFM), France. “nature seems unaware of our intellectual need for convenience and unity, and very often takes delight in complication and diversity.”
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