Abstract
Changes in the spontaneous activity of single cortical motor neurons induced by electrical stimulation of the unspecific mediocentral thalamus with various parameters were investigated with microelectrodes in the anesthetized rabbit. Stimulation with repetitive stimuli of low voltage, low frequency, and long pulse duration, which induces sleep in the waking animal, inhibits 77% of the reactive neurons; simultaneously the average discharge frequency decreases. On the contrary, stimulation at a higher frequency rate (75/sec) producing an arousal reaction activates 60% of the reactive cortical units. On the other hand, progressively longer pulse duration tends to increase the number of neurons reacting with decreased discharge frequency. The fact that the same thalamic substrate may under various stimulation conditions inhibit or activate the cortical neurons, and sometimes even the same cortical unit, provides new evidence for the existence of a functional duality in the mediocentral intralaminary thalamic system.
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