Abstract
This paper investigated the antifungal and antibiofilm activity of silver nanoparticles synthesized with Lycopersicon esculentum extracts against Candida species. Lycopersicon esculentum extracts obtained by homogenization were mixed with silver nitrate to synthesize silver nanoparticles. Analysis of the particle characteristics by UV–Vis spectrophotometry, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDAX), dynamic light scattering (DLS), and Fourier transform infrared spectroscopy (FT-IR) confirmed that the Lycopersicon esculentum extracts effectively served as reductants and capping agents. Minimum inhibitory concentration (MIC) tests were conducted to confirm antifungal activity against Candida species. In all the tested species, the silver nanoparticles inhibited the growth of Candida. Moreover, the SEM images of Candida species treated with silver nanoparticles synthesized using natural extracts of Lycopersicon esculentum showed that silver nanoparticles adhered to the surface of Candida, which induced pore formation in the membranes and prevented their normal growth. Ultimately, these abnormal forms of Candida were thought to be less able to form biofilms than normal Candida. The antifungal and antibiofilm activities of silver nanoparticles against Candida are expected to be utilized in various fields and contribute in particular to developments in nanomedicine.
Highlights
The synthesis of nanoparticles has been studied for some time, and various attempts have been made to apply them to advance the field of nanomedicine [1]
We examined the properties of silver nanoparticles synthesized by Lycopersicon esculentum extracts and their fungicidal activity against Candida species
We reported that Lycopersicon esculentum extract played a role in the synthesis of spherical nano-sized silver particles, acting as a reductant and capping agent
Summary
The synthesis of nanoparticles has been studied for some time, and various attempts have been made to apply them to advance the field of nanomedicine [1]. Silver nanoparticles are well known for their biocidal properties, which include antibacterial, antifungal, antiviral, and anticancer activities [2]. For this reason, silver nanoparticles take center stage as potential therapeutic biomolecules. As the tendency toward consideration of economic and environmental benefits becomes more pronounced, efforts to find efficient synthesis methods that do not involve hazardous and pollutive chemical agents have grown [3]. The most common silver nanoparticles synthesis method is a chemical synthesis method using sodium borohydride (NaBH4). Sodium borohydride reduces Ag+ ions to Ag0 in aqueous silver nitrate solution [5]
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