Abstract
Chromanone‐containing compounds have been reported to possess several important biological activities. As a part of our continuing effort for discovering potent anti‐inflammatory agents, a series of halogen‐containing 3‐benzylidenechroman‐4‐ones (1–15) were synthesized, and evaluated for their inhibitory effect on lipopolysaccharide (LPS)‐stimulated reactive oxygen species (ROS) production in RAW 264.7 macrophages. Compounds 4 and 10 exhibited significant inhibitory activity (IC50 = 5.09 ± 1.27 and 5.11 ± 0.51 μM, respectively) against LPS‐stimulated ROS production in RAW 264.7 macrophages.
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