Abstract
Objective: The objective of this study was undertaken to examine pancreatic lipase and tyrosinase inhibitory activities of Camellia mistletoe (Korthalsella japonica) extracts and conduct their antiproliferative activity on several human cancer (Hela, A375, HCT 116, HepG2 and A549) and normal cells (TK6) lines.Methods: The lipase inhibitory activity of acts of Camellia mistletoe extracts were determined from the hydrolytic reaction of p-nitrophenyl butyrate with pancreatic lipase and cytotoxicity against human cancer and normal cell lines were also evaluated using the MTT assay. The in vitro tyrosinase inhibitor potency of Camellia mistletoe extracts was estimated using mushroom tyrosinase.Results: Both methanol and ethanol extracts of Camellia mistletoe exhibited an inhibitory effect on lipase inhibition activity with IC50 values of 0.39 and 0.49 mg/ml, respectively. Moreover, Camellia mistletoe extracts were judged to be strongly active against the cancer cell lines, while they had no antiproliferative activity against the normal human cell lines. However, they had little inhibitory effects on tyrosinase activity.Conclusion: Camellia mistletoe extracts could be the good sources of natural lipase inhibition and anticancer agents with a great potential to be used in food and therapeutic fields.
Highlights
Medicinal plants are an important therapeutic aid for various ailments
The pancreatic lipase inhibitory effect of Camellia mistletoe was superior to those when various dietary plants were screened by Kim et al [17] and Conforti et al [18]
We found that Camellia mistletoe extracts fraction had a small inhibitory effect at the highest dose tested
Summary
Medicinal plants are an important therapeutic aid for various ailments. In recent times, focus on plant research has increased all over the world and a large body of evidence has collected to show immense potential of medicinal plants used in various traditional systems [1]. The increasing use of plant extracts in the food, cosmetic and pharmaceutical industries suggests that in order to find active compounds, a systematic study of medicinal plants is very important. Compounds from medicinal plants in the food and cosmetics industry have a central role and have a wide range of applications. Mistletoe extracts are used for the treatment of many diseases such as cancer, hypertension, and diabetes [3,4,5]. Korthalsella japonica (family Santalaceae), is a semiparasitic plant which is distributed in Jeju Island, Korea. There has been considerable interest in the antioxidant potential and antimicrobial activities of Camellia mistletoe extracts [6, 7]. The present study was aimed to evaluate inhibitory activities of lipase, tyrosinase and cancer cell proliferation by the methanol and ethanol extracts from Camellia mistletoe
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