Abstract
The flavonoids kaempherol, genistein, naringenin, quercetin, morin, rutin and quercitrin isolated from UFV-5’soybean’s cultivars were tested as inhibitors of aldose reductase. The best results were obtained by using morin and quercitrin.
Highlights
Flavonoids that are present in higher plants, mainly leguminous, have aroused interest because of their inhibitory action on aldose reductase[1,2,3]
The inhibitory action of flavonoids on aldose reductase (D-mannitol-l- phosphate-dehydrogenase of E. coli) in different concentrations of flavonoids (Table 1), demonstrates that a concentration of [] M is the best promoter of the inhibitory action of the enzyme
It confirms that the flavonoids morin and quercitrin presented higher inhibitory action relative to the enzyme
Summary
Flavonoids that are present in higher plants, mainly leguminous, have aroused interest because of their inhibitory action on aldose reductase[1,2,3]. Aldose reductase catalyses the reduction of glucose and galactose, producing sorbitol and dulcitol respectively, using NADH as a co-factor[4]. This enzyme has been found in many animal tissues, such as the retina, blood, the cornea, the sciatic nerve, the liver, kidneys and sperm. The excessive presence of sorbitol in diabetic rats and humans causes the formation of cataracts[2,5,6]. The purpose of the present study is to isolate, purify and identify flavonoidic compounds of the UFV-5’ soybean’s cultivar, as well as to test their inhibitory action in aldose reductase in vitro
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